Among the greatest benefits of red light therapy is that it does address some underlying causes or triggers of fibromyalgia, including chronic inflammation, oxidative stress, and psychological stress. For that reason, red light is considered a promising therapy for fibromyalgia sufferers (though it shouldn't be considered a cure).
A major scientific review that confirmed this was published in May 2019 by researchers from Taiwan, who analyzed nine published randomized controlled trials that collectively involved 325 fibromyalgia patients. Overall, about 95 percent of patients receiving LLLT demonstrated statistically significant improvement in their pain severity, fatigue, depression, and other factors, without any adverse side effects.
In the published review, the authors write: “Our results provided the most up-to-date and relevant evidence regarding the effects of LLLT in fibromyalgia.” The authors go on to say that “LLLT is an effective, safe, and well-tolerated treatment” for the disorder.
Increased Cellular Energy
Red light therapy’s ability to stimulate energy production within cells is at the heart of what makes it helpful for fibromyalgia sufferers. Increased energy production in cells means they can perform their specialized functions, protect themselves from pathogens, repair themselves, and replicate normally.
When this process goes in the other direction, however—meaning cellular energy production decreases—it can lead to a condition called mitochondrial dysfunction. Research has shown that this condition is responsible for a huge variety of conditions including, as a 2011 study shows, neurodegenerative diseases.
Red light has been shown to stimulate cellular metabolic functioning to reverse mitochondrial dysfunction. As Dr. Hamblin explains in a 2019 study published in Photonics: “Improved metabolic functioning is one of the most easily recognizable effects of [photobiomodulation], and increased intracellular ATP production is one the most strongly supported mechanisms of action.” This, in turn, stimulates the following beneficial processes.
Reduced Brain Inflammation
According to some researchers, fibromyalgia may be a central inflammatory disorder that may be caused by an abnormal cytokine release in the brain. Cytokines are small proteins released by immune system cells.
Research has shown that too many pro-inflammatory cytokines and not enough anti-inflammatory cytokines can cause inflammation of the central nervous system (a condition commonly found in fibromyalgia). NIR wavelengths can absorb into the brain to reduce chronic inflammation and regulate levels of both pro and anti-inflammatory cytokines. It also stimulates blood flow, which delivers nutrients and oxygen to brain cells and removes waste products and toxins.
Reducing inflammation can prevent further damage to the central nervous system, as well as the peripheral nervous system, which refers to all the nerves that are outside the brain and spinal cord. This can support the restoration of normal pain signaling.
Reduced Oxidative and Nitrosative Stress in the Brain
One prevailing theory about fibromyalgia is that it originates in neurochemical imbalances within the central nervous system. This was one main topic of a 2011 article titled, “The Science of Fibromyalgia,” which was published in the medical journal, Mayo Clinic Proceedings.
Fibromyalgia alters the balance of neurotransmitters that cause pain processing. For example, serotonin levels decrease, and levels of a neurochemical involved in pain signaling is known as “substance P” increase. These imbalances are associated with amplified pain signals, heightened sensitivity to even gentle stimuli, and an exaggerated response to painful stimuli.
Several studies confirm that red light helps correct these imbalances:
A 2016 study found that red light reduces oxidative stress in the brain, which helps normalize serotonin levels to ease depression in fibromyalgia patients.
An animal study showed that red light reduces nitrosative stress by reducing the concentration of nitric oxide (an overabundance of nitric oxide is linked to low levels of serotonin, and therefore to depression, especially in patients with chronic pain.
An overview of several clinical trials and animal studies shows improved cerebral blood flow to be another beneficial effect that red light therapy has on the brain.
Normalized Microbiomes in the Gastrointestinal Tract
As the ancient Greek physician Hippocrates reportedly once said, “All disease begins in the gut.” Research has shown that the majority of patients with fibromyalgia have chronic gastrointestinal problems, as doctor of chiropractic medicine Paul C. Breeding stated in a 2016 publication of the International Conference on Fibromyalgia and Chronic Pain: “The majority of patients with fibromyalgia have dyspepsia, Irritable Bowel Syndrome and other gastrointestinal problems.”
An animal study suggests that red/NIR light delivered to the abdomen can alter the gut microbiome in a beneficial way. It increases microbiome diversity, including a 10,000-fold increase in the proportion of beneficial bacteria after 14 days of treatment with NIR light. It is believed that this may be due to the anti-inflammatory effects of NIR light.
Neuronal Regeneration and Neuroprotection
Near-infrared light encourages neuronal regeneration in the brain as well as peripheral nerve repair, which can restore normal pain signaling. Red light therapy stimulates neurogenesis (growth of new neurons) and synaptogenesis (the brain’s ability to change). Red light also regulates neuronal function which can help restore normal CNS functioning.
Red light also has a neuroprotective effect on brain cells, which safeguards their survival and supports normal functioning. Even red light applied to other parts of the body appears to have a neuroprotective effect on the brain, possibly due to stem cell activation.
Increased Blood Circulation
Red light has also been shown to enhance the proliferation of endothelial cells, which form part of the tiny capillaries that deliver blood to the outermost regions of the body. More capillaries mean more oxygen and nutrient delivery to cells, and efficient waste removal.
Exercise, which also stimulates blood flow, can be excruciatingly painful for fibromyalgia patients. Improved blood flow from red light therapy treatment for fibromyalgia pain can be reduced, allowing patients to increase their daily activity levels.
Stem Cell Activation
Any time there is damage to cells anywhere in the body, stem cells are activated as part of the immune response. These “master cells” normally lie dormant in the bones (including the skull) where they are ready to mobilize as needed.
In the case of fibromyalgia, stem cells help reduce musculoskeletal pain. Stem cells, or the body’s “master cells,” mobilize to the site of pain (which signals injury or disease); there, they take on necessary roles. These can include modulating the immune system by decreasing inflammatory cytokines and by enhancing the number of anti-inflammatory cytokines. This regulation results in less inflammation—and less pain.
Red light has been shown to stimulate cellular migration of stem cells and to prevent abnormal cell apoptosis (cell death). One study showed that after 40-hour irradiation under 660nm LED lights, bone marrow stem cells migrated to the brain; in this case, toward brain cells damaged due to lack of oxygen and poor blood flow.
Improved Sleep
Insomnia is one of the effects of fibromyalgia. Not only does the inability to sleep diminish one’s quality of life, but it also prevents the body from spending enough time in what’s known as a “rest and digest” state, in which the parasympathetic nervous system calms the body and works on internal healing.
One way that red light therapy helps improve sleep is by stimulating the production of melatonin, a hormone that lets the body know when it’s time to sleep and wake up. Better sleep supports positive moods and better help.
Decreased Pain
Red light therapy can decrease pain, as in the case of a fibromyalgia patient who saw her pain levels drop from 8/10 to 0/10 after four days of consecutive at-home red light therapy treatments. She reported increased activity, which continued to increase once her pain level dropped to 0/10. In a follow-up three weeks after the therapy, the patient remained pain-free.
Red light reduces the hyper-excitability of pain receptors in fibromyalgia patients. It also stimulates a local release of nitric oxide, a vasodilator, which increases blood flow in the area.
Red light has been shown to reduce musculoskeletal pain by reducing inflammation and edema, promoting blood flow, and inducing analgesia. It has also been used clinically to treat neuropathic pain.
Peripheral Nerve Regeneration
Fibromyalgia pain is widespread throughout the body. Even though the disease is considered to be a disorder of the central nervous system, it directly affects the signaling that goes on between the CNS and the peripheral nervous system.
Some research has shown that red light can successfully regenerate nerves. Along with the other benefits of red light, such as increased cellular energy, reduced inflammation, reduced oxidative damage, and increased circulation, nerve regeneration could potentially help restore normal signaling between the nerve endings and pain receptors in the brain.