The mechanism of relieving pain using near-infrared light primarily relies on stimulating the body’s healing mechanisms through increased cellular energy and reduced inflammation.
A 2017 study co-authored by Hamblin examined the biological effects of infrared radiation. The study revealed that nerve cells respond well to the bio-stimulating effects of NIR light.
Pain Relief
Numerous studies have found that red light therapy has a beneficial pain-relieving effect. In several scientific papers, Hamblin has emphasized the treatment’s effectiveness at reducing inflammatory pain.
During a 2014 study by Iranian researchers, rats were divided into three groups, one of which was exposed to both 660nm red light, and 980nm low-level laser therapy for two weeks. Compared with the rats that were not treated, the treatment group showed improvement in neuropathic pain.
Many studies used lasers to deliver light to the body’s tissues, whereas other studies used LED devices. Although lasers concentrate the light more precisely than LED lights, the difference in terms of effectiveness is negligible since both devices are powerful enough to “drive” light photons into the body.
Recent advances in LED technology make red light therapy accessible to anyone outside of a research or clinical setting.
Nerve Regeneration
Without nerve regeneration, however, relief from pain is an ongoing struggle.
It’s not easy for the body to regrow nerve cells, but research has shown that it is possible. If the nerve cell itself is still alive, nerve fibers have a chance to regenerate, which can restore more normal nervous system communications and sensory function.
Reduced Inflammation
Many medical conditions and disorders are caused by chronic inflammation. If this is the cause of neuropathic pain, the first step toward relief is treating the inflammation.
Once all inflammation and primary causes are slowed or stopped, the key to improving neuropathic conditions is restoring normal nerve function. And one of the best ways to support this restoration is with NIR light therapy, which has been shown to reduce inflammation.
In 2017, Hamblin authored a scientific paper about red light therapy’s effectiveness at reducing chronic inflammation.
Eliminating underlying causes such as inflammation can prevent future nerve damage. If damage is already present (whether from injury or inflammation) In the case of nerve damage, there is a gap between healthy nerve cells and the damaged axons (nerve fibers) in an affected area.
In 2010, researchers from Japan published a study showing that red/NIR LED light therapy could promote nerve regeneration by reducing inflammation. The study found that the antioxidant properties of red/NIR light are conducive to nerve regeneration (oxidative stress leads to inflammation, which interferes with nerve functioning). In this study, red and NIR light therapy promoted nerve regeneration after three weeks of one-hour-per-day treatment.
Increased Blood Flow
An important finding during a 2017 study was that red light therapy stimulates the production of nitric oxide (not to be confused with the anesthetic nitric oxide). Nitric oxide contributes to vasodilation (the dilation of blood vessels), which decreases blood pressure and increases blood flow. The greater your circulatory capacity, the more nutrients and oxygen are available to all parts of the body to accelerate healing and potentially reduce chronic inflammation.
Stimulated Production of Schwann Cells and Fibroblasts
Closing the gap between healthy nerve cells and nerve fibers is necessary to restore nerve functioning. Red light therapy stimulates the production of Schwann cells (cells of the peripheral nervous system) and fibroblasts (cells in connective tissue). This has been shown to reduce inflammation and support restoration of normal nerve cell functioning.
Schwann cells and fibroblasts are the superstars of the body’s natural healing mechanisms.
Regenerating the connectivity in damaged nerves relies on Schwann cells. These highly specialized cells are essential to the health of the peripheral nervous system and play a crucial role in nerve development, function, maintenance, and regeneration. Schwann cells also form the myelin sheath, which is a protective layer that forms around nerves and allows electrical impulses to transmit quickly and efficiently along the nerve cells.
For Schwann cells to do their work, they require the assistance of fibroblasts. These cells produce collagen and other fibers that are necessary for rejoining severed or damaged tissue.
In the case of neuropathy, fibroblasts signal Schwann cells and stimulate them into forming a type of cord that rejoins the healthy nerve cells to damaged axons. This, in turn, guides the axons to regrow around an injured area and form a protective myelin sheath around the newly restored nerves.
Schwann cells and fibroblasts work in concert to repair nerve damage, and near-infrared light can support this process.
Increased Cellular Metabolism
When you’re sick, hungry, or exhausted and try to do too much, you know you only get sicker, or hungrier, or more exhausted. And it’s the same with your cells.
At the root of many chronic disorders lies a condition called mitochondrial dysfunction. This term broadly encompasses the inability of cells to produce enough energy. In effect, a depleted cell will struggle, which means it has to decide between performing its normal functions, or repairing and regenerating itself.
Stimulating energy production within the cells is key to optimal health in all of the body’s systems. While these mechanisms are not fully understood, research has shown that increasing cellular energy production supports healing.
The science supports the potential of red light therapy to treat peripheral neuropathy. The big question is …